M05: Describing the metabolome of sex variability

This project will employ a metabolome analysis of the systems under investigation described in the other projects above and extracts, namely mouse serum and urine, cell supernatants, and human serum and urine. We will then apply metabolomics to discriminate between different entities and to define organizational and regulatory profiles. Identifying sex-related metabolic pathways by comparing samples from individuals with DSD with typical male and female persons and combining this with the metabolic analysis of mouse models of sex development will allow us to decipher metabolic changes affected by chromosomal sex and hormone status.